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155 Depletion of HIF-1 shows impaired GSIS, due to the decreased basal and glucose-stimulated ATP concentration 155,156 (Fig

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lactis HN019 alone, at a dose of 10 billion CFUs per day, for 28 days increased stool frequency and reduced straining in a subgroup of those reporting three or fewer bowel movements per week at baseline (Ibarra 2018)

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