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Any rapid weight loss, including weight loss from a GLP-1 medication, can include some loss of muscle as well as fat

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Central Nervous System Appetite Modulation GLP-1 signaling also influences neural pathways involved in hunger and reward processing, as documented in clinical pharmacology research published in the NCBI [2] literature on incretin-based therapies

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In participants with metabolic dysfunction-associated steatotic liver disease (MASLD), retatrutide demonstrated an 82.4% reduction in liver fat content [4]