Key examples of top sellers in 2025 H1 include Novos Ozempic/Wegovy and Lillys Mounjaro/ZepBound
Only Tirzepatide is FDA approved
gradual weight loss through diet and exercise may provide modest symptom improvement Smoking cessation : Smoking increases hot flash risk and severity Environmental modifications : Maintaining cool ambient temperatures, using fans, wearing layered clothing, and keeping cold water accessible Stress reduction techniques : While mindfulness meditation, yoga, and paced respiration (slow, deep breathing) are commonly recommended, evidence for their effectiveness in reducing vasomotor symptoms is limited or inconsistent When lifestyle measures prove insufficient, pharmacological intervention becomes appropriate
10 In large adult randomized controlled trials, tirzepatide demonstrated substantial weight-loss efficacy, with mean body weight reductions of up to 20.9% over 72 weeks, surpassing outcomes observed with semaglutide monotherapy
All authors approved the manuscript in its final version
However, because GLP-1 receptor agonists slow gastric emptying and alter gastrointestinal motility, patients without a gallbladder may notice different digestive sensations compared to those with an intact biliary system
