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Nevertheless, inborn errors of purine metabolism should be excluded in patients with uric acid overproduction, particularly in men with disease onset under the age of 25 to 30 years and in women with gout onset in the early menopause and not due to other defined etiology such as CKD or thiazide or loop diuretic use

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Mol Immunol (2005) 42:9871014.10.1016/j.molimm.2004.09.029 3 MittalMSiddiquiMRTranKReddySPMalikAB