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Participants were studied at Baylor College of Medicine and underwent: (a) baseline studies of glucose tolerance test, physical function tests (gait speed, upper and lower extremity strength, and rapid 6-minute walk test to assess exercise capacity), DEXA and liver scans, calorimetry, tracer studies (palmitate and acetate), and muscle biopsy

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Compared to other otopathogens, NTHi-associated OM is associated with higher disease severity, treatment failure, recurrence, persistence and need for repeat surgery (Seppanen et al., 2020)

2.1.2 Molecular and cellular mechanisms underlying the pathogenesis of AD Amyloid plaques arise from the aggregation of A peptides, particularly A4 2 , which is harmful due to its tendency to form plaques and resist dissolving (Jarrett et al., 1993)

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