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For both, the N-terminal 75 residues were truncated to remove the chloroplast localisation signal present in the WT protein

This is true for not only GLP-1 but potentially for other peptide ligands where their activity is effectively reduced or terminated by metabolism to compounds considered to have little or no biological activity

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discovered that 18 genera, including Alistipes , Bacteroides , Barnesiella , Butyricimonas , Christensenella , Clostridium sensu stricto , Cosenzaea , Desulfovibrio , Dialister , Eisenbergiella , Faecalitalea , Megasphaera , Microvirgula , Mitsuokella , Parabacteroides , Proteiniborus , Terrisporobacter , and Acetobacteroides , were noticeably more prevalent in the hypertensive group [179]