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in trials, this appeared to be offset by the GLP-1 and GIP components, but careful monitoring in people with diabetes remains important
Neurosci Appl 3:103925 Leggio L, Hendershot CS, Farokhnia M et al (2023) GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders
To help manage symptoms, doctors recommend adjusting the medication dosage or introducing additional treatments to control nausea
However, these agents increase risk of intra-operative pulmonary aspiration according to a case report secondary to delayed emptying and presence of gastric residues despite fasting (108, 108) To prevent these events, the recent recommendations from the American Society of Anesthesiology guidelines suggest discontinuing GLP-1 receptor agonists 1 day prior in patients on daily dosing and 1 week prior in patients on weekly injection dosing (108)
Starting Retatrutide alone for 4 weeks gives you a clean baseline before layering in MOTS-C
Creating a calm, clean, and well-lit environment is essential for safety and helps reduce any anxiety you may feel
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