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If you are experiencing concerning side effects or need to discontinue tirzepatide for medical reasons (such as upcoming surgery or pregnancy), the most appropriate approach is to simply stop taking the medication and allow natural elimination to occur over the expected 3-to-4-week timeframe

Seek immediate medical attention (call 999 or attend A&E) if you experience persistent shivering, confusion, slurred speech, or drowsiness, as these may indicate hypothermia requiring urgent assessment

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and hospitalization for heart failure (HF) or CV death

The vial has now consumed roughly half a day to one full day of its 21-day room temperature budget

Switch to an alcohol-free formulation