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Neither study clearly answers the question of whether GLP-1 receptor agonists worsen symptoms among patients with preexisting mental health problems such as moderate or severe depression, they wrote

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In mice, obesity and the associated visceral adipose tissue inflammation result in insulin resistance, a process which appears to be mediated via increased synthesis and release of hepatic DPP-4, since eliminating hepatocyte Dpp4 expression suppresses inflammation and improves insulin sensitivity (82, 83)

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