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For instance, supplementation with 150 mg Zn for 12 weeks had a positive result [63], while administration of a smaller amount (15 mg) for 13 weeks did not have a positive effect, leading researchers to not recommend this dose [63]

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Its antioxidant properties and ability to cross the blood-brain barrier make it an interesting compound for neurological research

The role of CYP3A4 in APAP metabolism is controversial, with findings ranging from no significant contribution to it playing the primary role in APAP oxidation [33,3537]

ROS are typically produced at low levels under the physiological condition and are essential for maintaining cellular homeostasis and function

However, significant safety concerns and lack of regulatory approval limit their clinical utility