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A review on BPC-157 and gastric cytoprotection describes it as a stable gastric pentadecapeptide with anti-ulcer and tissue-protective effects and notes that it has been used in trials for ulcerative colitis

The simultaneous activation of NF-B and Nrf2 creates antagonistic interactions where p65, a subunit of NF-B, suppresses Nrf2 activity to drive the expression of ARE genes, such as HO-1, without p65s own transcriptional activity