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Magnetic NPs can generate heat or oscillate under an alternating magnetic field to disrupt lipid bilayers, while thermoresponsive polymers liquefy above 40 C, enabling brief, localized warming to trigger on-demand agonist release

These plateaus break naturally when patients maintain consistency

It is dose-dependent, more common during loading phase, and diminishes as tachyphylaxis develops over the first 710 days

Once symptoms are under control, a maintenance schedule of once or twice per month may be sufficient

Patients and providers alike can benefit from understanding these broader effects

If you live a busy lifestyle or deal with inflammation, detox effects can continue even longer