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As concomitant abuse of different drugs is common in todays society, the effects of GLP-1R agonists on the intake on multiple addictive drugs in a situation where the rats can choose between different drugs should be tested

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Anna Pastore, Francesco De Peppo And Anna Alisi have contributed equally to this work Key Points Weight loss is the mainstay of treatment of obesity-related metabolic-associated fatty liver disease (MAFLD)

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Old age is a factor causing significant changes in pharmacokinetics, mainly at the stage of distribution (increased content of adipose tissue and 1 acid glycoprotein, reduced water content and albumin concentration) and elimination (impaired renal function, slower hepatic metabolism) [153, 366]

The top-tier scientific journal, Nature, published the study