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Gross Clinical Assessment Assessment included edema (involving the face, upper and lower lip, snout, paws and scrotum (presented with extreme cyanosis)) that may be prominent, scored from 0 to 3 (0without swelling, 1mild swelling, 2moderate swelling and 3severe swelling), poor respiration as respiratory rate [5] and the number of fatalities after one or two applications of isoprenaline

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Mechanisms of Action (Preclinical) Angiogenesis: the combination supports new blood vessel formation via VEGF, FGF, and TGF- pathways, enhancing oxygenation and nutrient delivery to stressed tissues in research models

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), but the FDA approved it for the treatment of fibromyalgia because of research-backed clinical evidence supporting its use for this condition