In July 2026, an FDA advisory committee (the Pharmacy Compounding Advisory Committee, or PCAC) voted to recommend that several peptides including BPC-157, TB-500, KPV, and MOTS-c be considered for inclusion on the 503A compounding list
Contaminating bacteria can produce enzymes that degrade peptides
Harris JM, Chess RB (2003) Effect of pegylation on pharmaceuticals
U100: 0.1 = 10 (1 = 100 ), 225 mcg: 225 5000 /1 = 0.045 = 4.5 263 mcg: 263 5000 /1 = 0.052 = 5.3 300 mcg: 300 5000 /1 = 0.06 = 6 338 mcg: 338 5000 /1 = 0.068 = 6.8 375 mcg: 375 5000 /1 = 0.075 = 7.5 413 mcg: 413 5000 /1 = 0.083 = 8.3 450 mcg: 450 5000 /1 = 0.09 = 9 488 mcg: 488 5000 /1 = 0.098 = 9.8 525 mcg: 525 5000 /1 = 0.105 = 10.5 563 mcg: 563 5000 /1 = 0.113 = 11.3
doi: 10.1016/S1003-5257(15)30001-5
The compound exists in an interesting regulatory position