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Hydrogen peroxide mediated mitochondrial UNG1-PRDX3 interaction and UNG1 degradation

A main player in this is glutathione

The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]

Gnde ne kadar L-karnitin alnr

Glutathione is a powerful antioxidant that your body makes naturally from three amino acids: cysteine, glycine, and glutamic acid

In addition, studies examining the effects of MPH on the rat brain reported a decrease in the activity of antioxidant enzymes, such as CAT and SOD [71,72,73]