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Overall, existing clinical research provides compelling evidence that RCD-related molecular signatures and circulating DAMPs hold significant promise as predictive and monitoring biomarkers in melanoma immunotherapy, warranting further prospective validation ( Table 1 ) (197, 198)

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In the USA, the maximum dosage per day recommended by the manufacturer (MacNeil Consumer Healthcare) was reduced from 4000 mg (eight 500 mg pills) to 3000 mg (six 500 mg pills) in 2011[35]

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