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It reflects the body reaching a new equilibrium state where calorie intake matches expenditure at the lower weight

756 , 757 , 758 The signs of cognitive impairment that PCPs may detect include overt functional and communication changes as well as more subtle signs, such as irregularities in medication or appointment adherence, loss of control of chronic disease, weight loss, or increased emergency department visits or hospitalizations

For instance, in a prominent clinical trial involving patients without diabetes, participants on higher Tirzepatide dosages achieved weight reductions averaging around 20% or more within approximately 72 weeks

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Faber et al., 1998