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In some embodiments, the otic formulation comprises between about 0.0001% to about 10% by weight of the weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

The hyper-parameter minimum , which corresponds to the minimum cross-validation error, was selected through 10-fold cross-validation

1 Introduction Polycystic ovarian syndrome (PCOS) is the most prevalent and extensively researched endocrine disorder affecting women of reproductive age

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8g) shows that the backbone atoms in the CME_c binding mode are relatively stable for the first 300 ns, with deviations around 320 ns and 430 ns