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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

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10.1158/1078-0432.CCR-15-0589 33 TomohiroN.SakamotoK

Unlike retinoids or exfoliating acids, they do not typically cause irritation, peeling, or photosensitivity

This is not a formal ceiling because no FDA-approved limit exists, but it represents the upper range of what is supported by preclinical scaling and provider experience

Moreover, the ROS-induced increase in the activity of CXCL16, a chemokine essential for the migration of cytotoxic T cells in vitiligo, is also caused by UPR activation [23]