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[18] who showed that LC not only had antihypertensive effect but its supplementation also attenuated cardiac fibrosis by increasing prostacyclin production through arachidonic acid pathways

Animal evidence is much larger and has been the basis for almost all of the published mechanism work

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467 Under hyperglycemic conditions, GLP-1RAs regulate hypertension by inhibiting carotid body function

In total, however, the DPP-4 inhibitor class has demonstrated a good safety and tolerability spectrum that justifies the wide use of the class