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In OA, iron accumulation in the joint microenvironment is associated with oxidative stress and chondrocyte injury, potentially contributing to ferroptosis-related cartilage degeneration (38)

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No specific, confirmed DSIP receptor has been identified, making it unusual among characterised neuropeptides

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Combination with finerenone for cardiorenal protection Recently, in FIDELIO-DKD [52], FIGARO-DKD [53] and their pooled meta-analysis FIDELITY [11], finerenone has also been shown to reduce cardiovascular and renal events in CKD patients with diabetes