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Collectively, the synergistic action of AGE-RAGE signaling, metabolic rewiring, and oxidative stress in the DW microenvironment creates a powerful, self-reinforcing circuit that locks macrophages into a persistent M1 state, thereby perpetuating chronic inflammation and impeding the resolution of healing (Figure 3)

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Stephen Byrd: See, that's what's so interesting, Mike, [be]cause you've highlighted before to me that you believe AI could replace weaponry as really the anchor asset for U.S