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The most significant is the substantial caloric restriction that occurs as appetite suppression takes effect

In general: Unopened semaglutide should be stored between 36F and 46F After first use, some formulations allow limited semaglutide room temperature storage for a defined number of days

Others, particularly those with obesity, type 2 diabetes or other metabolic conditions, may benefit from prescription GLP-1 medications as part of a comprehensive treatment plan

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Ma, H., et al., Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis

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