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Acknowledgements The authors thank the members of the Levy and Thaiss labs for valuable discussions and input

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Mitochondria are referred to as power plants of cells because they supply cells with chemical energy

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Cytokines and growth factors such as angiotensin II, leptin, platelet-derived growth factor (PDGF), and TGF- stimulate NOX enzymes in both macrophages and HSCs, driving excessive ECM deposition