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Intriguingly however, very recent data on anti-CD20 B cell depleting agents might be showing some efficacy in progressive MS, although the effect of peripheral B cell depletion on PIRA cannot be interpreted as independent of its effect on silencing acute/adaptive inflammatory activity (Kappos et al., 2020)

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Acknowledgments The authors thank the Ophthalmology Department of Fujian Provincial Geriatric Hospital for providing experimental facilities and research platform support