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Semaglutide, the first dedicated GLP-1 obesity treatment, achieved 14.9% body weight reduction in the STEP 1 trial

Originally isolated from human gastric juice in the early 1990s by Croatian researchers, this 15-amino acid peptide has demonstrated an almost paradoxical ability to promote healing across diverse tissue types throughout the body

As such, it is involved in many biological processes, including the breakdown of fats, the reduction of serum cholesterol, serotonin activity modulation, gene expression, and insulin signal transduction

Studied in preclinical models for tendon, ligament and tissue repair, angiogenesis and gut-lining protection

There is a need to understand which regions of the cerebellar cortex are best suited for different disease conditions, should stimulation paradigms take into account zones, and when should the cerebellar nuclei be considered instead