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[PMC free article: PMC2199264] [PubMed: 17505466] 85

Useful in megaloblastic anemia

Oral solution prevents new formation by working internally, while topical products correct existing pigmentation at the surface level

doi: 10.3390/nu13082613 289

GHK-Cu's ability to upregulate SIRT1 expression provides a direct link between the peptide and established longevity pathways, suggesting that its anti-aging effects operate through well-understood biological mechanisms rather than mysterious or poorly characterized processes

It not only stabilizes Nrf2, but it also activates a number of cytoprotective genes (HO-1, NQO1, GCLC/GCLM, and other phase-II enzymes) that protect cells from lipid peroxides, restore glutathione balance, and keep mitochondria healthy