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Interestingly, bioinformatic analyses conducted on bulk tissue data obtained from healthy human brain tissue donors revealed that endothelial cells and microglia were the predominant senescent cell types, driven by CDKN1A/ p21 WAF1 /CIP1 (42) revealing potential differences in senescent cell types between healthy and diseased states

Similar weight loss, elevations in FFAs and BAT activation by G49 were observed in Adipo Cre control mice (Fig

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Footnotes Conflict of Interest The authors declare no conflict of interest