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Secondly, Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1

Still, insurance coverage and cost considerations mean both drugs remain relevant, and patient-centred conversations about therapy choice are critical. GLP-1s beyond weight loss as multi-system therapies Liver disease and metabolic steatohepatitis Non-alcoholic fatty liver disease (NAFLD) and the more severe metabolic dysfunction-associated steatohepatitis (MASH) have few effective pharmacologic treatments

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Advertisement While semaglutide works to mimic GLP-1 hormones, tirzepatide (like Mounjaro and Zepbound) is considered a dual agonist

Research demonstrates that GLP-1 drugs combined with lifestyle changes help patients lose 12-15% of their body weight over 68 weeks