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[7] [9] These contraindications are based on known metabolic pathways, clinical case reports, and established pharmacological principles, and are supported by clinical guidelines and expert consensus

However, adverse events, particularly nausea and digestive symptoms, were more common among participants taking GLP-1 drugs, and some stopped treatment due to side effects

For thicker subcutaneous tissue, slightly longer needles ensure reliable subcutaneous rather than intradermal placement

Numbness or tingling sensations in the hands and feet

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