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Participants on the 12 mg dose lost an average of 28.3% of their body weight over 80 weeks

Continued surveillance remains essential given the theoretical risk based on animal studies

doi:10.1038/s41421-024-00700-0 Compliance Statement This product is intended for laboratory research use only and is not approved for human or veterinary use.

A : They must implement a proactive medication de-escalation strategy under direct clinical supervision

Information about ongoing trials can be found via the ISRCTN registry (isrctn.com) and ClinicalTrials.gov

GLP-1 expression was significantly decreased on day 5 (0.56 0.18) and day 9 (0.60 0.14) (Fig