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(4) Seek emergency care if you experience pain so severe that you cant find a comfortable position to sit in, pain accompanied by nausea and vomiting, pain accompanied by fever and chills, blood in your urine, or trouble passing urine

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The SURMOUNT-1 clinical trial showed participants on 10mg lost an average of 21.4% of their body weight, roughly 49 pounds or 22 kilograms

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95% CI, 0.51 1.08), the latter having been demonstrated to have neutral effect on cardiovascular outcomes (263)