McCoy and colleagues reported that 5-day treatment of dissociated rat hippocampal neurons with Dihexa increased dendritic spine density approximately three-fold compared to vehicle control (~41 spines per 50 m of dendrite versus ~15 spines), with the increase reflecting both new spine formation and increased spine-head width consistent with synaptic maturation [2]
Across BMI strata, miscarriage rates were comparable between semaglutide users and controls, with no statistically significant differences detected
Reduce the risk of cardiovascular events in patients with diabetes and heart disease
Wegovy also requires a weekly injection but is specifically approved for chronic weight management in adults and children with obesity issues
These results led the FDA in 2024 to approve Wegovy, initially green-lit for weight loss, for a second indication: to reduce the risk of serious heart problems in adults with cardiovascular disease who are overweight or have obesity
Black SM, Beggs JD, Hayes JD, Bartoszek A, Muramatsu M, Sakai M and Wolf CR