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doi: 10.3389/fendo.2021.761834 Received 20 August 2021 Accepted 23 September 2021 Published 19 October 2021 Volume 12 - 2021 Edited by Peiyuan Yin, Dalian Medical University, China Reviewed by Pierre Larraufie, INRA UMR1319 Microbiologie de lAlimentation au Service de la Sant, France

Exposure to cold temperatures activates production of proteins including RNA-binding motif protein 3 (RBM3), which demonstrates neuroprotective effects and may help maintain muscle mass during periods of reduced activity

Deviation from these temperatures can compromise the medication's ability to regulate appetite and glucose metabolism

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Weight loss from microdosing is likely modest and short-term, highly variable, and not guaranteedand there is still the problem of long-term maintenance if new habits are not adopted and the drug is discontinued, Zimmermann says