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Synovial inflammation is associated with pain sensitization in patients with knee OA 46 , suggesting a role of pro-inflammatory mediators in this process 39

Luo Y, Yang S, Zeng H, Liu S, Zhang Y, Li JE, Liu J (2025) Both subcutaneous semaglutide and calorie restriction improves pancreatic cell hyperplasia and gut microbiota in high-fat diet-induced obese mice

Because the FDA removed semaglutide and tirzepatide from shortage in 2025, compounded versions now move through the personalization pathway, meaning a clinician documents a specific clinical reason, rather than mass copying of the brand drug

It'll be interesting to see how this impacts their global supply chain resiliency.

Gen Z led at 28%, followed by baby boomers (23%), millennials (22%), and Gen X (22%)