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Comparison of the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in depressed versus nondepressed patients

It functions as a coenzyme, mediating various reactions in energy production, and regulating processes like DNA repair, gene expression, and cellular responses to stress

[15] [16] The hypothalamic-pituitary-adrenal (HPA) axis tightly regulates cortisol production, and disruptions to this system can result from chronic stress, certain medications, tumours, or autoimmune conditions