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The improvement in HbA1c was twice as large in patients who, during observation, lost 5% or more their initial body weight than in those who did not ( 0.9% vs 0.5%

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For patients whose symptoms significantly impact quality of life, healthcare providers may consider evidence-based pharmacologic options such as certain SSRIs/SNRIs, gabapentin, oxybutynin, or fezolinetant (FDA-approved for moderate to severe vasomotor symptoms)

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The Role of Glucagon-Like Peptide-1 Receptor Agonists in Cognitive Decline and Dementia Prevention: A Systematic Review and Semiquantitative Synthesis. Journal of Mental Health and Human Behaviour , Aug