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Moreover, in both 4T1 breast cancer and B16F10 melanoma models, LN LECs undergo structure and gene expression remodeling even before cancer cell invasion (113)

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Studies in mice show that sucrose and umami stimuli can promote GLP-1 secretion from taste bud-like cells, reinforcing the link between nutrient detection and enteroendocrine signaling (61)

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For deeper context on metabolic signaling, GLP-1 and gut microbiome research may help explain why appetite regulation, inflammation, and microbial balance are often discussed together during menopause