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A new computational modelling study, published online ahead of print in Toxicon (Rahman et al, 2025), explores this potential relationship examining whether concurrent GLP-1 RA therapy could alter the duration of botulinum toxin effect across neurological and aesthetic applications

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Summary: Adults with B12 deficiency and nerve pain typically require 1 mg hydroxocobalamin injections intramuscularly on alternate days until symptoms improve, followed by maintenance injections every two months

A low density of GLP1R was found in the pancreatic acini (Table 2)

Rivier J, Spiess J, Thorner M, Vale W