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These agents simultaneously target multiple hormonal pathwaysGLP-1, GIP, glucagon, amylin, and othersto mimic the physiologic complexity of postprandial endocrine signaling, thereby offering a pharmacological surrogate for multisystemic benefits

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The researchers also found that the reduction in LFC was related to the amount of fat in the liver at the beginning of the study, as well as reductions in VAT, ASAT, and body weight in the tirzepatide groups

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MOTS-C peptide regulates glucose metabolism, activates fat burning and improves insulin sensitivity through mitochondrial signaling