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Design and evaluation of peptide dual-agonists of GLP-1 and NPY2 receptors for glucoregulation and weight loss with mitigated nausea and emesis

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Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision

Metformin elicits antitumour effect by modulation of the gut microbiota and rescues Fusobacterium nucleatum -induced colorectal tumourigenesis