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Senescence induction in colon (HTC116) and bladder (EJ) cancer cell lines, followed by an incubation with the B2M-ADC, led to the clearance of 35% of senescent cells

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It binds poorly to IGF-binding proteins, which normally sequester IGF-1 in the body, allowing it to remain active and available for a significantly longer period

Inhibits lipogenesis the conversion of dietary carbohydrates into stored body fat