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Common side effects include injection site reactions (burning, pain, swelling, redness), headache, mild diarrhea, and upset stomach

Consequently, decarboxylase inhibitors are a core component of DA replacement therapy

Anisimov, Vladimir Kh

has received research support from Bayer Schering Pharma and Patient-Centered Outcomes Research Institute (PCORI), and is a consultant for AbbVie Pharmaceuticals and Actavis

IGF-1 signaling also plays a role in maintaining BBB integrity by promoting the expression of tight junction proteins and inhibiting the breakdown of the extracellular matrix (Freese et al., 2017)