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This rule helps make sure you dont take your doses too close together

The specific functional logic is as follows: In addition to GPR activation, SCFAs (especially butyrate) cross the blood-brain barrier via monocarboxylate transporter 1 (MCT1) and inhibit HDAC1/2 in the hippocampus and prefrontal cortexbrain regions critical for mood regulation

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Penn AC, Williams SR, Greger IH (2008) Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum