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However, while usually described as an antagonist, Ex4(9-39) has also been described as an inverse agonist at the murine GLP-1R (Serre et al ., 1998)

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Fold changes were calculated relative to the AL group and log transformed subsequently for visualization in the heatmap

Imaging and densitometry analysis was performed by measuring the optical densities of specific bands using a GS-800 Calibrated Image Densitometer (Bio-Rad Laboratories Srl, Milan, Italy) or UVITEC Mini HD9 acquisition system (Alliance UVItec Ltd., Cambridge, UK)

GLP-1 binds receptors on beta cells

Their rescue level is intermediate, indicating some restoration of function but not as effectively as type 1