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In lupus, this tolerance breaks down

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Think of it as the frame that keeps skin firm and youthful

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The expression of ERK, p38 MAPK, and AP-1 can increase transcriptional activity within the NF-kB pathway, consequently triggering skin inflammation and accelerating the process of skin aging (87)

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Kerdsomboon K, Techo T, Limcharoensuk T et al (2022) Low phosphate mitigates cadmium-induced oxidative stress in Saccharomyces cerevisiae by enhancing endogenous antioxidant defence system

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