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In some embodiments, administration of a formulation or composition or device described herein, in conjunction with otic surgery, medical device implantation, and/or cell transplantation, reduces or prevents cell damage and/or death (e.g., auris sensory hair cell death and/or damage) associated with otic surgery, medical device implantation, and/or cell transplantation

Nature 536 , 104107 (2016)

For maximum effect, it is recommended to administer the drug as close to the affected area as possible

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JAMA 294 , 7180 (2005)