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By contrast, intermittent short-term central blockade may preserve efficacy and reduce tachyphylaxis [243]

Meanwhile, the overall number of patients treated with GLP-1R agonists increased sharply, with the mean annual incidence of new prescriptions rising from 0.22% during 2011-2014 to 0.60% during 2015-2018, and then further to 2.11% in the 2019-23 period