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Discontinuation rates due to adverse events were higher with orforglipron: 8.7% at 12 mg and 9.7% at 36 mg, compared with 4.5% and 4.9% for semaglutide 7 mg and 14 mg, respectively

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In particular, the alcohol intake is unaffected after treatment with either an agonist directed toward protein receptor 119 in the L cells that synthesize GLP-1 or the injection of a DPP-IV inhibitor (Marty et al., 2020)

This approval is important because it gives Singapore patients a regulated route to treatment